Postdoctoral Fellow-MSH-32076-151

Description Title: Postdoctoral Fellow (Req. 3023851)) Salary: According to UAW/Mount Sinai agreement, starting salary $73,588 Department: 866 - Department of Immunology and Immunotherapy Location: Brown Lab (Brian Brown), Hess Center for Science and Medicine, 5th Floor Department website: Laboratory website: Administrative Contact: Amanda Allen, MBA, HRM Responsibilities The Brown Laboratory is seeking highly motivated postdocs to lead projects aimed at identifying molecular factors that control ovarian and breast cancer dormancy and immune evasion. The candidate will utilize Perturb-map spatial functional genomics (Dhainaut et al. Cell 2022, Mollaoglu et al. Cell 2024) to determine how different receptors and ligands control ovarian and breast tumor growth, immune cell composition and response to immunotherapy. The goal of the project will be to identify therapeutic targets for enhancing immune-mediated elimination of metastatic ovarian and breast cancers including dormant cancer cells. Technical Duties: (include any protocols) Perform independent research in the area of tumor biology, including the application of spatial functional genomics to study factors contributing to tumor microenvironment composition. Studies will involve Pro-Code/CRISPR library generation, multiplex imaging, flow cytometry, spatial transcriptomics, mechanistic gene knockout studies, and therapeutic intervention experiments. Analysis of small and large datasets, working collaboratively with computational biologists. Write or assist in writing scientific papers and grants Collaborate closely with other scientists to conduct research Qualifications Qualifications: Ph.D. required Experience working in a research laboratory setting This position is covered by a collective bargaining agreement between the ISMMS and the Sinai Postdoctoral Organizing Committee - UAW. Wages and benefits: See Article 5 and 13 of The collective bargaining agreement found online at . Our mission at Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve. Mount Sinai Health System is committed to diversity and equal opportunity Compensation Statement The Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for this role is $73,588.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits. , 866 - Immunology and Immunotherapy - ISM, Icahn School of Medicine The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism." EOE Minorities/Women/Disabled/Veterans Employer Description Strength Through Diversity The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai's unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by: Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential. Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination. Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers. At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally. Explore more about this opportunity and how you can help us write a new chapter in our history! "About the Mount Sinai Health System: Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally. The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism." EOE Minorities/Women/Disabled/Veterans Compensation The Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

Qualifications: Ph.D. required Experience working in a research laboratory setting This position is covered by a collective bargaining agreement between the ISMMS and the Sinai Postdoctoral Organizing Committee - UAW. Wages and benefits: See Article 5 and 13 of The collective bargaining agreement found online at . Our mission at Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve. Mount Sinai Health System is committed to diversity and equal opportunity Compensation Statement The Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for this role is $73,588.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits. , 866 - Immunology and Immunotherapy - ISM, Icahn School of Medicine The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism." EOE Minorities/Women/Disabled/Veterans

The Brown Laboratory is seeking highly motivated postdocs to lead projects aimed at identifying molecular factors that control ovarian and breast cancer dormancy and immune evasion. The candidate will utilize Perturb-map spatial functional genomics (Dhainaut et al. Cell 2022, Mollaoglu et al. Cell 2024) to determine how different receptors and ligands control ovarian and breast tumor growth, immune cell composition and response to immunotherapy. The goal of the project will be to identify therapeutic targets for enhancing immune-mediated elimination of metastatic ovarian and breast cancers including dormant cancer cells. Technical Duties: (include any protocols) Perform independent research in the area of tumor biology, including the application of spatial functional genomics to study factors contributing to tumor microenvironment composition. Studies will involve Pro-Code/CRISPR library generation, multiplex imaging, flow cytometry, spatial transcriptomics, mechanistic gene knockout studies, and therapeutic intervention experiments. Analysis of small and large datasets, working collaboratively with computational biologists. Write or assist in writing scientific papers and grants Collaborate closely with other scientists to conduct research